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All trans-Retinal

CAS No. 116-31-4

All trans-Retinal( Retinaldehyde | Vitamin A aldehyde )

Catalog No. M19986 CAS No. 116-31-4

All-trans-retinal is a one of the major vitamin A metabolites in the retina. In physiological conditions all-trans-RAL is regenerated to the visual chromophore 11-cis-retinal.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    All trans-Retinal
  • Note
    Research use only, not for human use.
  • Brief Description
    All-trans-retinal is a one of the major vitamin A metabolites in the retina. In physiological conditions all-trans-RAL is regenerated to the visual chromophore 11-cis-retinal.
  • Description
    All-trans-retinal is a one of the major vitamin A metabolites in the retina. In physiological conditions all-trans-RAL is regenerated to the visual chromophore 11-cis-retinal.
  • In Vitro
    Cell Viability AssayCell Line:ARPE-19 cells Concentration:10 μM, 20 μM, 30 μM Incubation Time:16 h Result:Displayed a dose-dependent toxicity which included the morphological disruption of ARPE-19 cells.Western Blot Analysis Cell Line:ARPE-19 cells Concentration:10 μM, 30 μM Incubation Time:30 min Result:The phosphorylation of p53 at Ser 46 were detected prior to Bax activation in ARPE-19 cells.
  • In Vivo
    ——
  • Synonyms
    Retinaldehyde | Vitamin A aldehyde
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    116-31-4
  • Formula Weight
    284.44
  • Molecular Formula
    C20H28O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 50 mg/mL;Ethanol: 25 mg/mL
  • SMILES
    CC(\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C)=C/C=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sawada O et al. All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis. Exp Eye Res. 2014 Jun;123:27-36.
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