All trans-Retinal( Retinaldehyde | Vitamin A aldehyde )

Catalog No. M19986 CAS No. 116-31-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

All trans-Retinal
Note

Research use only, not for human use.
Brief Description

All-trans-retinal is a one of the major vitamin A metabolites in the retina. In physiological conditions all-trans-RAL is regenerated to the visual chromophore 11-cis-retinal.
Description

All-trans-retinal is a one of the major vitamin A metabolites in the retina. In physiological conditions all-trans-RAL is regenerated to the visual chromophore 11-cis-retinal.
In Vitro

Cell Viability AssayCell Line:ARPE-19 cells Concentration:10 μM, 20 μM, 30 μM Incubation Time:16 h Result:Displayed a dose-dependent toxicity which included the morphological disruption of ARPE-19 cells.Western Blot Analysis Cell Line:ARPE-19 cells Concentration:10 μM, 30 μM Incubation Time:30 min Result:The phosphorylation of p53 at Ser 46 were detected prior to Bax activation in ARPE-19 cells.
In Vivo

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Synonyms

Retinaldehyde | Vitamin A aldehyde
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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1.Sawada O et al. All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis. Exp Eye Res. 2014 Jun;123:27-36.

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